Gene Therapies Redefined
With the support of an Enterprise Ireland grant, we are exploring innovative techniques to design viral capsids. Our methods utilise artificial intelligence (AI) and computational tools to modify specific regions on the capsid surface, thereby improving interactions between the virus and receptors. Our goal is to enhance the design of engineered adeno-associated virus (AAV) vectors through advanced molecular screening techniques, which will improve the efficiency of delivering therapeutic genes to target cells. These precise solutions hold significant potential for addressing complex medical conditions where traditional treatments may prove limited.
Predicting Protein Interactions
We’re employing the latest technology to analyse large sets of protein structures. This allows us to predict how proteins fold and interact. Our approach combines advanced tools and molecular simulations, systematically exploring different binding arrangements. This data-driven method provides valuable insights into binding affinities, interacting components and the overall structure of peptide and protein complexes. These findings hold the promise of being leveraged for the development of innovative therapies with enhanced tissue specificity, improved delivery, or increased therapeutic effectiveness.
Discovery to Validation
We work closely with academic research partners to combine advanced computational biology with experimental validation. Working with researchers at the Pharmaceutical and Molecular Biotechnology Research Centre (PMBRC) at the South East Technological University in Waterford, we are undertaking cell based studies to validate key aspects of our AI guided viral vector engineering platform. This integrated approach helps translate computational discoveries into experimentally validated technologies, supporting the development of next-generation biologics and gene therapies.
Get in touch
We look forward to the opportunity to work with you remotely or on-site to support your biopharmaceutical development and manufacturing needs. To contact us, please email contact@appliedbiopharm.com with your information and a brief description of your enquiry and we will respond as soon as possible. If you prefer to speak with someone directly, please feel free to call on
Ire: +353 87 3634486
UK: +44 20 37696567
US: +1 917 7225368
(UK/GMT)
